Speakers

This is our speakers

Prof. Miho Terunuma, D.D.S., Ph.D

Division of Oral Biochemistry

Surname: Terunuma

First name: Miho

Date of Birth: 6 April 1974

Gender:             Female

Nationality:  Japan 



Contact information:


Division of Oral Biochemistry                                                                         Email: mterunuma@dent.niigata-u.ac.jp                                                                                                             

Niigata University Graduate School of Medical and Dental Sciences                  Lab Office Phone: +81 25 227 2827

2-5274 Gakkocho-dori, Chuo-ku                                                                                         Lab Fax: +81 25 227 2827

Niigata 951-8514

Japan



Current position:


Vice Dean, Graduate School of Medical and Dental Sciences, Niigata University

Vice Dean, Faculty of Dentistry, Niigata University

Professor, Division of Oral Biochemistry, Niigata University, Graduate School of Medical and Dental Sciences



Previous education: 


Doctor of Dental Surgery 

  March 31st, 2000, Kyushu University, School of Dentistry, Fukuoka, Japan


Ph.D. in Dentistry (Molecular and Cellular Biochemistry)

  March 31st, 2004, Kyushu University, Graduate School of Dentistry, Fukuoka, Japan


Postgraduate Certificate in Academic Practice in Higher Education

February 23rd, 2016, University of Leicester, Leicester, UK



Work experience:


Niigata University, Graduate School of Medical and Dental Sciences, Division of Oral Biochemistry

Professor (from August 2016)


University of Leicester, College of Medicine, Biological Sciences and Psychology, Department of Neuroscience, Psychology and Behaviour, Leicester, UK

Lecturer in Neuroscience (October 2013 – July 2016)


Tufts University, School of Medicine, Department of Neuroscience, Boston, MA, USA

Research Associate (July 2009 - October 2013) 

Postdoctoral Associate (June 2008 - June 2009)

Advisor: Prof. Stephen J. Moss


University of Pennsylvania, School of Medicine, Department of Neuroscience, Philadelphia, PA, USA

Postdoctoral Fellow (August 2005- May 2008)

Advisor: Prof. Stephen J. Moss


University of London, School of Pharmacy, Department of Pharmacology, London, UK

Visiting Researcher (October- December 2004)

Advisor: Dr. Jasmina N. Jovanovic


University College London, The Medical Research Council (MRC) Laboratory for Molecular Cell BIology, Department of Pharmacology, London, UK

Visiting Student (July- October 2003)

Advisor: Prof. Stephen J. Moss


Pohang University of Science and Technology, Department of Life Science, Pohang, South Korea

Visiting Student (November 2000- February 2001)

Advisor: Prof. Sung-Ho Ryu


Kyushu University, School of Dentistry, Department of Dental Science, Fukuoka, Japan

Research Fellow (April 2004- July 2005)

Predoctoral Researcher (April 2000- March 2004)

Advisor: Prof. Masato Hirata (Laboratory of Molecular and Cellular Biochemistry)



Clinical experience:


Miyake Dental Clinic, Fukuoka, Japan

   Part time dentist, General dentistry (April 2000 - July 2005)     



Editorial positions & community services:


The Japanese Society for Neurochemistry: Director, 2021 – present

The Japanese Society for Neurochemistry: Young scientist training committee, 2019 – present

The Japanese Biochemical Society, Council member, 2021 - present

The Japanese Biochemical Society, Kantoh Branch: Council member, 2021 – present

The Japanese Society of Neuropsychopharmacology: Council member, 2018 – present

Neuropsychopharmacology Report: Associate editor



PUBLICATIONS:


  1. Komatsu A, Iida I, Nasu Y, Ito G, Harada F, Kishikawa S, Moss SJ, Maeda T, Terunuma M. (2022) Ammonia induces amyloidgenesis in astrocytes by promoting amyloid precursor protein translocation into the endoplasmic reticulum. J Biol Chem. 2022 May;298(5):101933.


  1. Yamada Y, Nihara J, Trakanant S, Kudo T, Seo K, Iida I, Izumi K, Kurose M, Shimomura Y, Terunuma M, Maeda T, Ohazama A. (2021) Perivascular Hedgehog responsive cells play a critical role in peripheral nerve regeneration via controlling angiogenesis. Neurosci Res. 2021 Jun 23: S0168-0102(21)00144-9.


  1. Iida I, Konno K, Natsume R, Abe M, Watanabe M, Sakimura K, Terunuma M. (2021) A comparative analysis of kainate receptor GluK2 and GluK5 knockout mice in a pure genetic background. Behav Brain Res, 405:113194.


  1. Li X, Terunuma M, Deeb TG, Wiseman S, Pangalos MN, Nairn AC, Moss SJ, Slesinger PA. (2020) Direct Interaction of PP2A Phosphatase with GABAB Receptors Alters Functional Signaling. J Neurosci. 40(14):2808-2816.


  1. Yoshihara M, Tsujimura T, Suzuki T, Nagoya K, Shiraishi N, Magara J, Terunuma M, Inoue M. (2020) Sustained laryngeal transient receptor potential vanilloid 1 activation inhibits mechanically induced swallowing in anesthetized rats. Am J Physiol Gastrointest Liver Physiol. 319(3):G412-G419.


  1. Terunuma M. (2018) Diversity of structure and function of GABAB receptors: a complexity of GABAB-mediated signaling. Proc Jpn Acad Ser B Phys Biol Sci. 94(10):390-411.


  1. Newman EL, Terunuma M, Wang TL, Hewage N, Bicakci MB, Moss SJ, DeBold JF, Miczek KA. (2018) A role for prefrontal cortical NMDA receptors in murine alcohol-heightened aggression. Neuropsychopharmacology. 43(6):1224-1234.


  1. Munoz MB, Padgett CL, Rifkin R, Terunuma M, Wickman K, Contet C, Moss SJ, Slesinger PA. (2016) A role for the GIRK3 subunit in methamphetamine-induced attenuation of GABAB receptor-activated GIRK currents in VTA dopamine neurons. J. Neurosci. 36(11): 3106-14. 


  1. Vien TN, Modgil A, Abramian AM, Jurd R, Walker J, Brandon NJ, Terunuma M, Rudolph U, Maguire J, Davies PA, Moss SJ. (2015) Compromising the phosphodependent regulation of the GABAAR β3 subunit reproduces the core phenotypes of autism spectrum disorders. Proc. Natl. Acad. Sci. U S A. 112(48): 14805-10.


  1. Terunuma M**, Haydon PG, Pangalos MN, Moss SJ**. (2015) Purinergic receptor activation facilitates astrocytic GABAB receptor calcium signalling. Neuropharmacology. 88:74-81. **Co-corresponding author 


  1. Huyghe D, Nakamura Y, Terunuma M, Faideau M, Haydon P, Pangalos MN, Moss SJ. (2014) Glutamine synthetase stability and subcellular distribution in astrocytes are regulated by γ-aminobutyric type B receptors. J. Biol. Chem. 289(42): 28808-15.


  1. Abramian AM, Comenencia-Ortiz E, Modgil A, Vien TN, Nakamura Y, Moore YE, Maguire JL, Terunuma M, Davies PA, Moss SJ. Neurosteroids promote phosphorylation and membrane insertion of extrasynaptic GABAA receptors. Proc. Natl. Acad. Sci. U S A. 2014.


  1. Terunuma M**, Revilla-Sanchez R, Quadros IM, Deng Q, Deeb TZ, Lumb M, Sicinski P, Haydon PG, Pangalos MN, Moss SJ**. Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory. J. Neurosci. 34(3): 804-816, 2014. ** Co-corresponding author


  1. Vithlani M, Hines RM, Zhong P, Terunuma M, Hines DJ, Revilla-Sanchez R, Jurd R, Haydon PG, Rios M, Brandon N, Yan Z, Moss SJ (2013) The ability of BDNF to modify neurogenesis and depressive-like bahaviors is dependent upon phosphorylation of tyrosine residues 365/367 in the GABA(A)-receptor γ2 subunit. J. Neurosci. 33(39): 15567-77.


  1. Kretschmannova K, Hines RM, Revilla-Sanchez R, Terunuma M, Tretter V, Jurd R, Kelz MB, Moss SJ, Davies PA. (2013) Enhanced tonic inhibition influences the hypnotic and amnestic actions of the intravenous anesthetics etomidate and propofol. J. Neurosci. 33(17): 7264-73.


  1. Padgett CL, Lalive AL, Tan KR, Terunuma M, Munoz MB, Pangalos MN, Martinez-Hernandez J, Moss SJ, Lujan R, Lüscher C, Slesinger PA. (2012) Methamphetamine-evoked depression of GABAB receptor signaling in GABA neurons of the VTA. Neuron 73(5): 978-989.


  1. Odajima J, Wills ZP, Ndassa Y, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak SH, Quadros IM, Newman J, Das M, Jecrois ME, Yu Q, Li N, Bienvenu F, Moss SJ, Greenberg ME, Marto JA, Sicinski P. (2011) Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Developmental Cell 21(4): 655-668. Selected to the cover of the journal.


  1. Vithlani M, Terunuma M, Moss SJ. (2011) The dynamic modulation of GABAA receptor trafficking and its role in regulating the plasticity of inhibitory synapses. Physiological Review 91(3): 1009-1022. Review. Selected to the cover of the journal.


  1. Deng Q*, Terunuma M*, Fellin T, Moss SJ, Haydon PG. (2011) Astrocytic activation of A1 receptors regulates the surface expression of NMDA receptors through a src kinase dependent pathway. Glia 59(7): 1084-1093. *Contributed equally to this work


  1. Terunuma M, Pangalos MN, Moss SJ. (2010) Functional modulation of GABAB receptors by protein kinases and receptor trafficking. Adv. Pharmacol. 58: 113-22. Review. Books.


  1. Terunuma M*, Vargas KJ*, Welkins ME, Raminez O, Jaureguiberry M, Pangalos MN, Smart TG, Moss SJ and Couve A. (2010) Prolonged activation of NMDA receptors promotes dephosphorylation and alters post-endocytic sorting of GABAB receptors. Proc. Natl. Acad. Sci. U S A. 107(31): 13918-23. *Contributed equally to this work 


  1. Boyer S, Clancy S, Terunuma M, Revilla-Sanchez R, Thomas S, Moss SJ, and Slesinger PA. (2009) Direct Interaction of GABAB Receptors with M2 Muscarinic Receptors Enhances Muscarinic Signaling. J. Neurosci. 29(50): 15796-19809


  1. Tretter V*, Revilla-Sanchez R*, Houston C*, Terunuma M*, Havekes R*, Florian C*, Jurd R*, Vithlani M, Michels G, Couve A, Sieghart W, Brandon NJ, Abel T, Smart TG, Moss SJ. (2009) Deficits in spatial memory correlate with modified γ-aminobutyric acid type A receptor tyrosine phosphorylation in the hippocampus. Proc. Natl. Acad. Sci. U S A. 106(47): 20039-44. *Contributed equally to this work


  1. Fellin T, Halassa MM, Terunuma M, Succol F, Takano H, Frank M, Moss SJ, Haydon PG. (2009) Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. Proc. Natl. Acad. Sci. U S A. 106(35): 15037-42.


  1. Vargas KJ*, Terunuma M*, Tello JA, Pangalos MN, Moss SJ, Couve A. (2008) The availability of surface GABA B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neurons. J. Biol. Chem. 283(36): 24641-8. *Contributed equally to this work


  1. Terunuma M, Xu J, Vithlani M, Sieghart W, Kittler J, Pangalos M, Haydon PG, Coulter DA, Moss SJ. (2008) Deficits in phosphorylation of GABA(A) receptors by intimately associated protein kinase C activity underlie compromised synaptic inhibition during status epilepticus. J. Neurosci. 28(2): 376-84.


  1. Kanematsu T, Mizokami A, Terunuma M, Takeuchi H, Hirata M. (2008) Identification of a novel signaling molecule and elucidation of its cellular functions – Development of an interface between neuroscience and oral health science. J. Oral Bioscience 49(4): 244-258. Review.


  1. Pathak HR, Weissinger F, Terunuma M, Carlson GC, Hsu FC, Moss SJ, Coulter DA. (2007) Disrupted dentate granule cell chloride regulation enhances synaptic excitability during development of temporal lobe epilepsy. J. Neurosci. 27(51): 14012-22.


  1. D'Ascenzo M, Fellin T, Terunuma M, Revilla-Sanchez R, Meaney DF, Auberson YP, Moss SJ, Haydon PG. (2007) mGluR5 stimulates gliotransmission in the nucleus accumbens. Proc. Natl. Acad. Sci. U S A. 104(6): 1995-2000.


  1. Kuramoto N, Wilkins ME, Fairfax BP, Revilla-Sanchez R, Terunuma M, Tamaki K, Iemata M, Warren N, Couve A, Calver A, Horvath Z, Freeman K, Carling D, Huang L, Gonzales C, Cooper E, Smart TG, Pangalos MN, Moss SJ. (2007) Phospho-dependent functional modulation of GABAB receptors by the metabolic sensor AMP-dependent protein kinase. Neuron 53(2): 233-47. 
  2. Yanagihori S, Terunuma M, Koyano K, Kanematsu T, Ho Ryu S, Hirata M. (2006) Protein phosphatase regulation by PRIP, a PLC-related catalytically inactive protein--implications in the phospho-modulation of the GABAA receptor. Adv. Enzyme Regul. 46: 203-22.


  1. Kanematsu T, Takeuchi H, Terunuma M, Hirata M. (2005) PRIP, a novel Ins(1,4,5)P3 binding protein, functional significance in Ca2+ signaling and extension to neuroscience and beyond. Mol. Cells. 20(3): 305-14. Review.


  1. Goto H, Terunuma M, Kanematsu T, Misumi Y, Moss SJ, Hirata M. (2005) Direct interaction of N-ethylmaleimide-sensitive factor with GABA(A) receptor beta subunits. Mol. Cell. Neurosci. 30(2): 197-206.


  1. Terunuma M, Jang IS, Ha SH, Kittler JT, Kanematsu T, Jovanovic JN, Nakayama KI, Akaike N, Ryu SH, Moss SJ, Hirata M. (2004) GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J. Neurosci. 24(32):7074-84.


  1. Kanematsu T, Terunuma M, Goto H, Kuratani A, Hirata M. (2004) The life cycle of the GABA(A) receptor and its regulating molecules. Nippon Yakurigaku Zasshi. 123(2): 105-12. Review. Japanese.


  1. Yoshimura K, Takeuchi H, Sato O, Hidaka K, Doira N, Terunuma M, Harada K, Ogawa Y, Ito Y, Kanematsu T, Hirata M. (2001) Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1alpha. J. Biol. Chem. 276(21): 17908-13. 



Books Chapter:


  1. Hirata M, Kanematsu T, Terunuma M. (2004) A novel protein that regulates GABA(A) receptor function. 

The Brain Science Review. Published, March 1st 2004, Kubapro press. Japanese.


  1. Kanematsu T, Terunuma M, Hirata M. (2002) A novel protein that regulates GABAergic signalings. 

The elucidation of brain function. Published, May 1st 2002, Gaiya press. Japanese.



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